Endocrine Abstracts

We present, the first reported case of twins conceived by Assisted Reproductive Technology (Gamete Intra-fallopian Transfer Therapy; GIFT), both diagnosed to have Complete Androgen Insensitivity Syndrome (CAIS).Eighteen-year-old twins presented to the Endocrine clinic with primary amenorrhoea. They were conceived by GIFT and were born premature at 34 weeks and delivered by forceps. On examination, they were two 18 year olds with normal female appearance,...

Introduction: Parathyroid cancer is a rare endocrine malignancy and constitutes 0.005% of all cancers. It can recur in 50% of cases. The first recurrence commonly occurs within 3 years of the original diagnosis. Hypercalcaemia is the main cause of morbidity and mortality. We present a case of a 62-year-old male patient who had an atypical lung nodule recurrence with normal calcium and PTH levels, six years following resection of a functioning parathyroid cancer.<p class="a...

Background: Hyponatremia is associated with increased, inpatient mortality and length of stay and correct management necessitates doing appropriate investigations for accurate diagnosis of the cause.Aim: The aim of this audit was to identify, the number of medical and surgical patients admitted with hyponatreima over a 4-week period; number of cases with mild (<135) vs moderate to severe cases of hyponatremia (<130 mmol/l); determine if hyponatre...

Aim: To study those factors which influence the sensitivity and positive predictive value of combined MIBI scintigraphy and ultrasound scan in the localisation of parathyroid adenomas.Method: A retrospective review of notes was done of 150 patients with hypercalcaemia referred to the Endocrine outpatients’ clinic, between the years 2002–2005.Notes of 135 patients with biochemical evidence of primary hyperparathyroidism (P...

ObjectivesTo compare our practice, at Sunderland Royal Hospital, to the recommendations of NIH Consensus Development Programme (February 2002) and BAES.MethodRetrospective audit of patients who had adrenal mass on imaging studies done between 1996–2004.Patients who had incidentally detected adrenal mass were included. Patients with symptoms and / or signs suggesting adrenal mass pr...

Introduction: Pathological fractures are uncommon in young patients and raise concern about malignancy. Brown tumour (osteitis fibrosa cystica) is a rare benign resorptive bone lesion reported in approximately 3% of patients with primary hyperparathyroidism (PHPT). These have become uncommon in contemporary practice and have the potential to be misdiagnosed because of radiological similarities to other bone diseases especially malignancy.We present a case where the first prese...

A 58-year-old lady presented to hospital with abdominal pain, nausea, and tiredness, and was referred to endocrinology with symptomatic hyponatraemia (serum Na+ 112 mmol/l). Six months previously her serum sodium was normal. She was euvolaemic, and adrenal insufficiency and thyroid dysfunction were excluded. Laboratory investigations were suggestive of syndrome of inappropriate antidiuretic hormone (SIADH) and no causative medications were identified. A CT of her th...

A 59-year-old gentleman presented to the Medical Admission Unit with facial and ankle oedema following a dog bite. He did not have any significant past medical history. Initially, he was treated for angioedema. His oedema worsened to anasarca, blood pressure rose and was found to be hypokalaemic. Echocardiogram showed a normal left ventricular ejection fraction. Urine protein creatinine ratio was <0.5 g/24 h. Vasculitic and autoimmune screen were negative. Eight weeks late...